The Impact of SARS-CoV-2 on Male Infertility: A Systematic Review and Meta-Analysis of Cohort Studies.
Quick Take: COVID-19 infection significantly correlates with impaired male fertility parameters, demanding consideration in patient counseling and workup.
💡 Clinical Impact
- Patient Counseling: Advise male patients with a history of SARS-CoV-2 infection about potential fertility implications when discussing reproductive health.
- Diagnostic Consideration: Include prior SARS-CoV-2 infection in the differential for new-onset or unexplained male infertility.
📊 Evidence Breakdown
- Evidence Grade: 8/10
- Analysis: A systematic review and meta-analysis of cohort studies robustly links SARS-CoV-2 infection to negative impacts on male fertility, aggregating findings across multiple observational datasets.
🩺 Practice Recommendation
Informative—Incorporate into patient counseling and diagnostic consideration immediately. Further research is needed to guide specific therapeutic interventions.